细辛减毒增效提取工艺初探

Preliminary Study of the Extract Technology for Asarum Aimed at Enhancing Effect and Reducing Toxicity

目的:结合药理学指标及马兜铃酸A含量,初步探讨细辛减毒增效提取工艺。方法:采用高效液相色谱法,对不同溶媒提取物中马兜铃酸A含量进行测定,结合止咳、祛痰效应指标,对细辛减毒增效工艺进行初步评价。结果:细辛挥发油及正己烷提取物均未检出马兜铃酸A,止咳效果显著。结论:细辛挥发油及正己烷提取物止咳效应增强,肾毒性成分降低。

Objective ：Determine the contents of aristolochic acid A which was connected with pharmacological parameter and prliminarily study the extract technology for asarum aim at enhancing effect and reducing toxicity.Methods：Determined the contents of different extractive by HPLC and evaluate the different extract technology by connecting with antitussive and expectorant index.Results： Aristolochic acid A was not detected in volatile oil and different extractive.Obvious effect was found in arresting coughing.Conclusion： The volatile oil of asarum and N-butanol extractive strengthen the effect on expelling phlegm and arresting coughing, kidney toxicity was reduced.