透皮无创血糖监测技术中的关键电化学问题研究

Study of Key Electrochemical Problems in Transdermal Noninvasive Glucose Monitoring

本研究分析并解决了在透皮无创血糖监测技术中的几个关键电化学问题。针对葡萄糖传感器的线性范围,提出使用新的校正方程标定葡萄糖传感器,使得传感器的线性范围增加到原来的20倍以上。针对透皮无创血糖监测中特有的"有限空间",建立了新的扩散模型进行分析,确立了适于无创血糖检测的采样时刻。针对传感器长时间血糖监测中电极损耗,提出"电极掩膜"的概念,避免了传感器电极的失效。在解决以上关键问题后,得出了较好的动物实验数据。以有创检测值为对照,97个无创血糖值中,70.10%的数据属临床准确,29.90%的数据为临床相对准确。本研究为透皮无创血糖监测技术的实现和优化奠定了基础。

Several key problems were analysed for the transdermal noninvasive glucose monitoring. A modified calibration equation was proposed for the high-sensitivity glucose biosensor due to its narrow linear range. The new equation has increased the sensors＇linear range by 20 times. A new diffuse model was constructed for the electrode system of glucose sensor, aiming at the unique ＂finite space＂ electrochemical problem in transdermal technique. In addition, electrode masks were utilized to solve the problem of electrode loss in longtime glucose monitoring. In animal in-vivo experiments, 70.1% of the noninvasive glucose data points were clinically accurate, while the remains were clinically acceptable. All solutions mentioned above were based on both theoretical analysis and experimental validation, promoting the realization and optimization of transdermal noninvasive glucose monitoring techniques.