马齿苋的化学成分

Chemical constituents from Portulaca oleracea L.

目的研究马齿苋的化学成分。方法利用硅胶、Sephadex-LH-20、ODS等柱色谱方法进行分离纯化,根据理化性质及波谱数据(1H-NMR、13C-NMR)进行结构鉴定。结果从马齿苋中分离得到8个化合物,分别鉴定为2,5-二羧基吡咯(1 H-pyrrole-2,5-dicarboxylic acid,1)、5-羟基-2-羧基吡啶(5-hydroxy-2-pyridinecarboxylic acid,2)、马齿苋酰胺B(oleracein B,3)、3,4-二羟基苯甲酸(3,4-di-hydroxybenzoic acid,4)、木栓酮(friedelin,5)、4α-甲基-3β-羟基-木栓烷(4α-methyl-3β-hydroxyl-friedelan,6)、羽扇豆醇(lupeol,7)、环(亮氨酸-苯丙氨酸)(cyclo(L-leucinyl-L-tyrosinyl),8)。结论化合物1、2、8首次从马齿苋属中分离得到。

Objective To separate and identify the chemical constituents of the extract from the Portulaca oleracea L. Methods The compounds were separated by repeated silica gel SephadexLH-20 and ODS. The structures of these isolated compounds were identified by analysis of their spectral data （1H-NMR, 13C-NMR） and chemical properties. Results Eight compounds were isolated from Portulaca oleracea L. and their structures were identified as 1H-pyrrole-2,5-dicarboxylic acid（ 1 ） ,5-hydroxy-2-pyridinecarboxylic acid （ 2 ）, oleracein B （ 3 ）, 3,4-dihydroxybenzoic acid （ 4 ）, friedelin （ 5 ）, 4α-methyl-3β-hydroxylfriedelan （ 6 ）, lupeol （7）and cyclo （L-leucinyl-L-tyrosinyl） （8）. Conclusions Compounds 1,2 and 8 are isolated from Portulaca for the ftrst time.