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垂体腺苷酸环化酶激活肽对缺血性脑损伤的保护作用

The protective effect of pituitary aclenylate cyclase activating polypeptide on ischemic neuronal damage
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摘要 垂体腺苷酸环化酶激活肽（PACAP）是一种新发现的神经肽，具有多种生物学活性。近年来PACAP的神经保护和神经营养作用越来越引起人们的注意。在缺血性脑损伤中，它能减少兴奋性氨基酸的释放，清除自由基，抑制炎性细胞趋化及神经元和小脑颗粒细胞的凋亡等，且PACAP相对分子质量小，能完全通过血脑屏障，为临床治疗缺血性脑损伤提供新的途径。
作者 黄淑霞(综述) 初桂兰(审校)
机构地区 天津医科大学总医院儿科
出处 《国际儿科学杂志》 2009年第6期595-596,611,共3页 International Journal of Pediatrics
关键词 垂体腺苷酸环化酶激活肽 缺血性脑损伤 脑保护
分类号 R977.6 [医药卫生—药品] R743.31 [医药卫生—神经病学与精神病学]
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参考文献22

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国际儿科学杂志
2009年 第6期

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