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转录因子GATA3和T—bet与支气管哮喘的关系

The relationship between transcfiption factor GATA-3/T-bet and asthma
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摘要 转录因子GATA3与T-bet是近年关注较多的转录因子之一，其参与了辅助T细胞（Th）1／Th2的分化调节。GATA3为Th2发展的关键调节子，其过表达可使气管上皮下纤维化程度明显增加，而T-bet主要调节Th0向Th1分化，并在一定程度抑制Th2的分化。支气管哮喘被认为是一种Th2偏移性疾病，调节T-bet／GATA3的平衡可使Th1／Th2恢复平衡，达到有效控制哮喘的作用。
作者 吴勇(综述) 唐章华(审校) 董文斌(审校)
机构地区 泸州医学院附属医院儿保科
出处 《国际儿科学杂志》 2009年第6期631-633,共3页 International Journal of Pediatrics
关键词 转录因子 哮喘
分类号 R734.2 [医药卫生—肿瘤] R562.25 [医药卫生—呼吸系统]
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参考文献21

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国际儿科学杂志
2009年 第6期

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