皮肌炎和多发性肌炎的免疫发病机制
被引量：1
Immunopathogenesis of dermatomyositis and polymyositis
摘要
皮肌炎和多发性肌炎（DM／PM）的发病机制尚未完全清楚。感染导致的分子模拟以及变性的自身抗原作为疾病的启动因子，导致遗传易感个体免疫细胞包括B细胞、T细胞、树突细胞、吞噬细胞等功能和分化异常以及体液免疫发生改变，从而引起细胞因子和化学分子不适当产生及炎症反应，导致骨骼肌肉损伤以及其他系统受累。该文按照免疫反应发生的过程，系统地对DM／PM免疫发病机制进行综述。
出处
《国际儿科学杂志》
2009年第6期649-651,共3页
International Journal of Pediatrics
参考文献19
-
1Pachman LM, Lipton R, Ramsey-Goldman R, et al. History of inffection before the onset of juvenile dermatomyositis: results from the National Institute of Arthritis and Museuloskeletal and Skin Diseases Research Registry. Arthritis Rheum, 2005,53(2) : 166-172.
-
2Massa M, Costouros N, Mazzoli F, et al. Self epitopes shared between human skeletal myosin and Streptococcus pyogenes M5 protein are targets of immune responses in active juvenile dermatomyositis. Arthritis. Rheum, 2002,46 ( 11 ) : 3015-3025.
-
3Casciola-Rosen L,Nagaraju K,Plotz P,et al.Enhanced antoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. J Exp Med, 2005,201 (4) :591-601.
-
4Komura K, Fujimoto M, Matsushita T, et al. Prevalence and clinical characteristics of anti-Mi-2 antibodies in Japanese patients with dermatomyositis. J Dermatol Sci,2005,40(3):215-217.
-
5Greenberg SA, Pinkus JL, Pinkus GS, et al. Interferon-alpha/beta-mediated innate immunemechanisms dermatomyositis. Ann Neurol, 2005, 57 ( 5 ) : 664-678.
-
6Greenberg SA, Pinkus GS, Amato AA, et al. Myeloid dendritic cells in inclusion-body myositis and polymyositis. Muscle Nerve, 2007,35 ( 1 ) : 17- 23.
-
7Schwab N, Waschbisch A, Wrobel B, et al. Human myoblasts modulate the function of antigen-presenting cells. J Neuroimmunol, 2008,200( 1-2 ) : 62- 70.
-
8De Paepe B, De Bleecker JL. Beta-cehmokine receptor expressien in idiopathic inflammatory myopathies. Muscle Nerve, 2005,31 (5) : 621-627.
-
9Nagaraju K, Rider LG, Fan C,et al.Endothelial cell activation and neovascu- larization are prominent in dermatomyositis. J Autoimmune Dis, 2006,3 : 2.
-
10Howard OM, Dong HF, Yang D, et al. Histidyl-tRNA synthetase and aspar- aginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells. J Exp Med, 2002,196(6) :781-791.
同被引文献15
-
1谢瑶,卢昕,王国春.肌炎特异性抗体在多发性肌炎和皮肌炎中的意义[J].中华风湿病学杂志,2005,9(11):645-649. 被引量：11
-
2Kurihara Y, Shishido T, Oku K, et al. Polymyositis associated with autoimmune hepatitis, primary biliary cirrhosis, and autoim- mune thrombocytopenic purpura [ J ]. Mod Rheumatol, 2011,21 (3) :325 -329.
-
3Matsumoto K,Tanaka H, Yamana S,et al. Successful steroid ther- apy for heart failure due to myocarditis associated with primary biliary cirrhosis[J]. Can J Cardiol, 2012,28(4) :515 -516.
-
4Castro C, Gourley M. Diagnosis and treatment of inflammatory myopathy: issues and management [ J ]. Ther Adv Musculoskelet Dis, 2012,4(2) :111 - 120.
-
5Dorph C, Englund P, Nennesmo I,et al. Signs of inflammation in both symptomatic and asymptomatic muscles from patients with polymyositis and dermatomyositis [ J]. Ann Rheum Dis, 2006, 65(12) : 1565 -1571.
-
6Migueletto BC, Nero AE, Domingues EZ, et al. Primary biliary cirrhosis and myopathy: an uncommon association [ J ]. Rev Hosp Clin Fac Med Sao Paulo, 1999,54 ( 5 ) : 165 - 168.
-
7Maeda MH, Tsuji S, Shimizu J. Inflammatory myopathies associ- ated with anti-mitochondrial antibodies [ J ]. Brain, 2012,135 ( Pt 6) :1767 - 1777.
-
8Kraemer P, Sagui E, Brosset C, et al. Inclusion myositis associat- ed with primary biliary cirrhosis of the liver [ J ]. Presse Med, 2003,32(10) :460.
-
9张红,周华,毛继芳,秦美华.多发性肌炎、皮肌炎患者的肌电图研究[J].中国临床实用医学,2009,3(6):41-42. 被引量：3
-
10张欣,史旭华,张烜,崔全才,张奉春.原发性胆汁性肝硬化的临床与肝脏病理相关性研究[J].中华风湿病学杂志,2011,15(2):75-78. 被引量：7
-
1胡泽华,林树林,黄玲玲,农凤秋,何康成,李薇.重症手足口病儿童脑脊液中淋巴细胞亚群的变化[J].广东医学,2016,37(19):2931-2933. 被引量：2
-
2江建宁.慢性活动性乙型肝炎患者外周血T淋巴细胞亚群与血清HBV－DNA的关系[J].广西医科大学学报,1995,12(3):368-370. 被引量：1
-
3李萍丽,杨宗利.支气管哮喘的健康教育[J].中国社区医师（医学专业）,2008,10(9):147-147.
-
4李勇（综述）,谭德勇,台虹（审校）.HIV-1相关的免疫性血小板减少性紫癜发生的分子机制[J].国际检验医学杂志,2007,28(6):554-555. 被引量：4
-
5黎莉,阿祥仁.高原地区老年肺心病患者血清一氧化氮和一氧化氮合酶水平的变化[J].中国老年学杂志,2009,29(14):1829-1830. 被引量：2
-
6樊均明,李甫罡,冯胜刚,杨满.IgA肾病免疫发病机制及免疫抑制治疗[J].西部医学,2013,25(2):161-163. 被引量：19
-
7马丽,王丽英,侯广庆,赵金凤,吴东海.皮肌炎/多发性肌炎59例长期随访[J].中华风湿病学杂志,2001,5(1):59-61. 被引量：9
-
8习东,宁琴.自身免疫紊乱和重症肝病[J].国外医学（流行病学．传染病学分册）,2003,30(3):171-173.
-
9王南芳.自身免疫性肝炎26例临床诊疗体会[J].中国当代医药,2009,16(22):200-200.
-
10杨晓.免疫抑制剂在肾小球疾病中的应用[J].临床肾脏病杂志,2010(2):52-54.
