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NFκB与成人T淋巴细胞白血病关系的研究进展 被引量：1

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摘要 在成人T淋巴细胞白血病(ATL)细胞中,人类T细胞白血病Ⅰ型病毒(HTLV-Ⅰ)非结构基因编码的TAX蛋白对调节病毒的复制和核因子κB(nuclear factor kappa B,NFκB)的激活起关键作用。NFκB是一类细胞核转录因子,它能通过经典的TAX蛋白激活途径或者通过不依赖TAX蛋白的途径而活化,使得宿主细胞CD4^+T淋巴细胞内一系列与细胞增殖存活有关的基因表达,如细胞因子、细胞凋亡调控蛋白、抗凋亡蛋白等,最终细胞无限增殖和转化导致ATL的发生,近些年NFκB已被作为治疗ATL的分子靶点。
作者 高琰 王辉
机构地区 新乡医学院医学检验系
出处 《国际检验医学杂志》 CAS 2009年第11期1097-1098,1100,共3页 International Journal of Laboratory Medicine
关键词 NF-ΚB 基因产物 tax 白血病淋巴瘤 T细胞 急性 HTLV-Ⅰ相关 人类嗜T淋巴细胞病毒1型
分类号 R733.71 [医药卫生—肿瘤]
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参考文献15

  • 1Karin M. Nuclear factor kappaB in cancer development and progression [J]. Nature, 2006, 441(7092): 431-436.
  • 2Taylor GP. Molecular aspects of HTLV-I infection and adult T-cell leukaemia/lymphoma[J]. J Clin Pathol, 2007, 60(12): 1392-1396.
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同被引文献16

  • 1Yasunaga J,Matsuoka M.Human T-cell leukemia virus type Ⅰ induces adult T-cell leukemia:from clinical aspects to molecular mechanisms cancer control[J].Cancer Control,2007,14(2):133-140.
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  • 3Fryrear KA,Durkin SS,Gupta SK,et al.Dimerization and a novel Tax speckled structure localization signal are required for Tax nuclear localization[J].J Virol,2009,83(11):5339-5352.
  • 4Yasunaga J,Matsuoka M.HTLV-Ⅰ and leukemogenesis[J].Uirusu,2006,56(2):241-249.
  • 5Lodewick J,Lamsoul I,Polania A,et al.Acetylation of the human T-cell leukemia virus type 1 Tax oncoprotein by p300 promotes activation of the NF-kappaB pathway[J].Virology,2009,386(1):68-78.
  • 6Fukuda RI,Tsuchiya K,Suzuki K,et al.Human T-cell leukemia virus type Ⅰ tax down-regulates the expression of phosphatidylinositol 3,4,5-trisphosphate inositol phosphatases via the NF-kappaB pathway[J].J Biol Chem,2009,284(5):2680-2689.
  • 7Harhaj NS,Sun SC,Harhaj EW.Activation of NF-kappa B by the human T cell leukemia virus type Ⅰ Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase[J].J Biol Chem,2007,282(6):4185-4192.
  • 8Yu Q,Minoda Y,Yoshida R.HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein[J].Biochem Biophys Res Commun,2008,365(1):189-194.
  • 9Carmody RJ,Ruan Q,Palmer S,et al.Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade[J].Science,2007,317(5838):675-678.
  • 10Hishiki T,Ohshima T,Ego T,et al.BCL3 acts as a negatire regulator of transcription from the human T-cell leukemia virus type Ⅰ long terminal repeat through interactions with TORC3[J].J Biol Chem,2007,282(39):28335-28343.

引证文献1

国际检验医学杂志
2009年 第11期

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