摘要
前列腺癌（PCa）骨转移是常见的临床问题，骨转移有多种病态表现，文献中把由恶性肿瘤骨转移引起的病理性骨折、脊髓压迫、高钙血症以及需手术治疗或放射治疗的骨并发症统称为骨相关事件（SRE）。大多数PCa患者的生存时间较长，在疾病进展过程中约70％将发生骨转移，PCa骨转移患者5年生存率为25％，中位生存时间3年。
出处
《中华医学杂志》
CAS
CSCD
北大核心
2009年第42期3019-3021,共3页
National Medical Journal of China
参考文献32
-
1Coleman RE. Metastatic bone disease : clinical features, pathophysiology and treatment strategies. Cancer Treat Rev, 2001,27:165-176.
-
2Saad F, Gleason DM, Murray R, et al. Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer. J Natl Cancer Inst, 2004,96:879-882.
-
3Nam RK, Jewett MA, Krahn MD. Prostate cancer: 2. Natural history. CMAJ, 1998,159:685-691.
-
4Adami S. Bisphosphonates in prostate carcinoma. Cancer, 1997, 80 : 1674-1679.
-
5Clarke NW, McClure J, George NJ. Osteoblast function and osteomalacia in metastatic prostate cancer. Eur Urol, 1993,24: 286 -290.
-
6Clarke NW, McClure J, George NJ. Morphometric evidence for bone resorption and replacement in prostate cancer. Br J Urol, 1991,68:74-80.
-
7Gamero P, Buchs N, Zekri J, et al. Markers of bone turnover for the management of patients with bone metastases from prostate cancer. Br J Cancer, 2000,82:858-864.
-
8Demers LM, Costa L, Lipton A. Biochemical markers and skeletal metastases. Cancer, 2000,88:2919-2926.
-
9Brown JE, Cook RJ, Major P, et al. Bone turnover markers as predictors of skeletal complications in prostate cancer, lung cancer, and other solid tumors. J Natl Cancer Inst, 2005,97:59-69.
-
10Hussain SA, Weston R, Stephenson RN, et al. Immediate dual energy X-ray absorbtiometry reveals a high incidence of osteoporosis in patients with advanced prostate cancer before hormonal manipulation. Br J Urol, 2003,92:690-694.
同被引文献29
-
1Nam RK,Jewett MA,Krahn MD.Prostate cancer:2.Natural history.CMAJ,1998,159:685-691.
-
2Coleman RE.Metastatic bone disease; clinical features,pathophysiology and treatment strategies.Cancer Treat Rev,2001,27:165-176.
-
3Carlin BI,Andriole GL.The natural history,skeletal complications,and management of bone metastases in patients with prostate carcinoma.Cancer,2000,88:2989-2994.
-
4Saad F,Gleason DM,Murray R,et al.Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer.J Natl Cancer Inst,2004,96:879-882.
-
5Riggs BL,Khosla S,Melton LJ 3rd.Sex steroids and the construction and conservation of the adult skeleton.Endocr Rev,2002,23:279-302.
-
6Hussain SA,Weston R,Stephenson RN,et al.Immediate dual energy X-ray absorbtiometry reveals a high incidence of osteoporosis in patients with advanced prostate cancer before hormonal manipulation.Br J Urol,2003,92:690-694.
-
7Greenspan SL,Coates P,Sereika SM,et al.Bone loss after initiation of androgen deprivation therapy in patients with prostate cancer.J Clin Endocrinol Metab,2005,90:6410-6417.
-
8Kiratli BJ,Srinivas S,Perkash I,et al.Progressive decrease in bone density over 10 years of androgen deprivation therapy in patients with prostate cancer.Urology,2001,57:127-132.
-
9Morote J,Morin JP,Orsola A,et al.Prevalence of osteoporosis during long-term androgen deprivation therapy in patients with prostate cancer.Urology,2007,69:500-504.
-
10Shahinian VB,Kuo YF,Freeman JL,et al.Risk of fracture after androgen deprivation for prostate cancer.N Engl J Med,2005,352:154-164.
二级引证文献10
-
1周辉,孙宏斌,黄文斌,徐郑,苏江浩,朱佳庚,贾瑞鹏,刘军.良恶性前列腺组织中基质细胞表型特征改变及意义[J].中华医学杂志,2012,92(8):516-519. 被引量：4
-
2林国文,叶定伟,姚旭东,张世林,戴波,张海梁,沈益君,朱耀,朱一平,施国海,马春光,肖文军,秦晓健.低剂量酮康唑治疗晚期去势抵抗性前列腺癌的疗效观察[J].中华医学杂志,2012,92(8):520-523. 被引量：8
-
3叶定伟.紫杉类药物在前列腺癌治疗中的进展和意义[J].中华医学杂志,2013,93(4):241-242. 被引量：2
-
4周萍,林煜荣,黄马平,谢克基,汤平.2-DG对雄激素非依赖型前列腺癌细胞多西紫杉醇化疗敏感性的作用[J].中华医学杂志,2013,93(40):3230-3234. 被引量：1
-
5龚云,王明秀,黄玉珠.5α-还原酶抑制剂对前列腺癌内分泌治疗患者生活质量的影响及护理分析[J].国际护理学杂志,2014,33(9):2570-2572. 被引量：3
-
6张翠,毕宇,马晓云.血清PSA、PAP联合检测对前列腺癌的诊断价值及雌激素对其的影响[J].国际医药卫生导报,2016,22(19):3011-3014. 被引量：1
-
7陶红,陈文军.血清PSA、PAP联合检测对前列腺癌诊断价值及雌激素对其影响研究[J].中国生化药物杂志,2017,37(5):365-367. 被引量：4
-
8庞华.转移性去势抵抗性前列腺癌化疗后预后的影响因素[J].实用癌症杂志,2014,29(7):763-765. 被引量：3
-
9郝斌,马志方,王东文.去势抵抗性前列腺癌个体化药物治疗的研究[J].临床医学进展,2017,7(2):123-129. 被引量：1
-
10胡君,王婷.多种化学因素对前列腺细胞连接蛋白Cx43的影响及对前列腺肿瘤治疗意义的研究进展[J].世界肿瘤研究,2015,5(1):8-14.
-
1张碧煌,吴志勇.采用帕米膦酸二钠（博宁）治疗恶性肿瘤骨转移致骨疼痛24例临床观察[J].世界医学杂志,2000,4(6):79-80.
-
2赵坚,刘健.乳腺癌骨转移的诊断与治疗现状[J].中国医药导报,2008,5(8):23-24. 被引量：6
-
3藕院林,颜蕴文,王本忠.乳腺癌骨转移相关分子机制及诊治[J].中华内分泌外科杂志,2012,6(3):198-199.
-
4刘统南.骨髓增生异常综合征与急性髓细胞白血病的病态造血特征分析[J].深圳中西医结合杂志,2015,25(10):118-119.
-
5邱志兵,李朝先,等.以非呼吸道症状为首发表现的肺癌28例临床分析[J].中国综合临床,2001,17(1):53-53.
-
6刘永连.癌前病变面面观[J].祝您健康,1994,0(2):33-33.
-
7郭晋纲,顾倩.正电子发射断层显像诊断乳腺癌骨转移的应用价值[J].中国药物与临床,2012,12(12):1584-1585.
-
8杨晓蓉.放射性核素治疗肿瘤骨转移78例临床分析[J].中外医疗,2010,29(28):90-90.
-
9殷凤,李书权.二磷酸盐治疗肿瘤相关骨并发症研究现状[J].国外医学（肿瘤学分册）,1999,26(5):313-315.
-
10邓娜,周珩,于灏.双膦酸盐在治疗恶性肿瘤骨转移相关并发症中研究[J].临床军医杂志,2016,44(4):405-407. 被引量：8
