颈动脉僵硬度在脑梗死危险预警中的意义

The significance of taking carotid artery stiffness as the early warning of cerebral infarction

目的:应用超声测量计算脑梗死不同程度危险人群颈动脉僵硬度指数(SI),探讨颈动脉僵硬度与颈动脉粥样硬化间关系,为脑梗死的早期预防提供依据。方法:应用彩色多普勒超声诊断仪对40例高血压中、高危患者以及40例高血压低危患者行颈动脉M型超声检查,测量颈总动脉前后壁在心脏收缩期和舒张期的内径,计算SI。并通过对血清高敏C反应蛋白(hs-CRP)观察,评定动脉粥样硬化与动脉僵硬度的关系。结果:①高血压中、高危组SI及hs-CPR明显高于高血压低危组(P<0.05),且两者呈正相关;②在调整年龄、性别、吸烟、家族史后,血压、血糖、血脂仍对动脉僵硬度增加起着极为积极的作用。结论:颈动脉僵硬度反映了临床前期颈动脉功能变化的特征,为脑梗死危险人群的预警提供了更早的信息。

Objective：To measure and calculate the carotid arterial stiffness index（SI） in different degree of atrisk cerebral infarction by ultrasonograph.According to the relationship between carotid artery stiffness and carotid atherosclerosis,it ispossible to provide an early prevention for cerebral infarction.Methods：The carotid artery of 40 high-risk cases and the 40 mild dangerous cases with hypertension were assessed by M type ultrasonic of color Doppler ultrasonography,calculation of SI by means of the diameter of common carotid artery wall in the systolic and diastolic cardiac cycle were performed.Changing of serum high sensitive C-reactive protein（hs-CRP） to assess the relationship between atherosclerosis and arterial stiffness.Results：①The SI and hs-CPR of hypertension on the high-risk group were higher than the mild dangerous group obviously,and had positively correlation.②After the age,sex,smoking and family history were adjusted,the blood pressure,blood glu-cose and blood fat are still playing an extremely positive role on arterial stiffness increasing.Conclusion：Carotid arterial stiffness reflects the characteristic of the functional change of carotid artery in preclinical,and provides an earlier warning for those who tend to suffer cerebral infarction.