缺血性脑血管病苍白球铁沉积的危险因素MR诊断价值

The risk factors for globus pallidus iron deposition in patients with ischemic cerebrovascular disease

目的:探讨缺血性脑血管病患者苍白球铁沉积的MR征象。方法:对968例缺血性脑血管病患者脑MRI进行回顾性研究,对苍白球铁沉积信号进行观察同时分析其患病的相关因素。结果:MRI梯度回波序列有助于早期、方便无创地观测到脑组织内铁沉积现象,苍白球铁沉积的危险因素为年龄、血胆固醇浓度、椎动脉狭窄程度。结论:金属铁在脑组织内可能存在"小脑-脑干-基底节(苍白球)"这一代谢通路,年龄的增长,血胆固醇代谢障碍及椎动脉逐渐狭窄引起脑干小脑等部位供血不足,使该铁质转运通路受损,铁无法正常排泄,沉积于内侧苍白球区域。

Objective：To investigate the risk factors causing globus pallidus iron deposition in patients with ischemie eerebrovaseular disease. Methods： The brain MRI images from 968 isehemie cerebrovaseular patients were studied retrospectively, iron deposition in glohus pallidus was observed,at the same time, analysis was performed with SPSS. Results： MILl gradient-echo sequence helped to observe the iron deposition phenomenon in brain tissue early, non-invasively and easily. The risk factors of iron deposition in Globus pallidus were age, serumcholesterol concentration, and vertebral artery stenosis. Conclusion：Iron in the brain may have the metabolic pathway of ＂cerehellum-brain stem-basal ganglia （Globus pallidus）＂. Age, metabolism disorder of cholesterol and vertebral artery stenosis cause brain stem-cerebellum isehemie, which damage the access for iron metabolizability, thereby leading to iron deposits in the medial globus pallidus.