Decreased serum prohepcidin concentration in patients with polycythemia vera

Objective： Iron deficiency is a common complication in patients with polycythemia vera （PV）. Hepcidin is a principal regulator of iron homeostasis. The aim of our study was to assess prohepcidin, a hepcidin precursor, and other iron status pa- rameters in the serum of PV patients. Methods： The study was performed in 60 patients （F/M 26/34） aged 38-84 （66＋ 10） years. The control group consisted of 20 healthy volunteers, age and sex matched. The following parameters were determined in blood serum samples： prohepcidin concentration, iron content, unsaturated iron binding capacity （UIBC）, total iron binding capacity （TIBC）, transferrin saturation （TfS）, and concentrations of ferritin and soluble transferrin receptor （sTfR）. Results： All PV patients showed significantly lower levels of prohepcidin, higher levels of sTIR and TIBC compared to the control group. 40% of the patients from the study group showed concentrations of ferritin below the normal range and significantly lower levels of serum iron and TfS, and significantly higher levels of sTIR, UIBC and TIBC in comparison with the rest of the study group. In this group of patients, prohepcidin concentrations were significantly lower than those in other patients. Conclusion： The results indicate that PV patients suffer from iron metabolism disorders. The decreased serum level ofprohepcidin in PV patients may be a result of iron deficiency.

客观的铁缺乏是在有红血球增多症 vera (PV ) 的病人的普通复杂并发症。Hepcidin 是铁动态平衡的一个主要管理者。我们的学习的目的是在 PV 病人的浆液估计 prohepcidin，一位 hepcidin 先锋，和另外的铁地位参数。学习在 60 个病人(F/M 26/34 ) 被执行的方法变老 38 ∼84 (66 ± 1 0 ) 年。控制组由 20 个健康志愿者，匹配的年龄和性别组成了。下列参数在血浆液样品被决定：prohepcidin 集中，熨满意的、不饱和的铁有约束力的能力(UIBC ) ，全部的铁绑定能力(TIBC ) ， transferrin 浸透(TfS ) ，和含铁锡和可溶的 transferrin 受体(sTfR ) 的集中。所有 PV 病人显著地显示出的结果 prohepcidin 的底层，与控制组相比的 sTfR 和 TIBC 高级。从学习组的 40% 病人在正常范围下面并且显著地显示出含铁锡的集中浆液铁和 TfS 的底层，并且与学习组的其余部分比较的 sTfR， UIBC 和 TIBC 显著地高级。在这组病人， prohepcidin 集中是比在另外的病人的那些显著地低的。结果显示那 PV 的结论病人们受不了铁新陈代谢混乱。在 PV 病人的 prohepcidin 的减少的浆液水平可以是铁缺乏的结果。