超声波法制备唑嘧璜草胺纳米粉体

Preparation of flumetsulam nanoparticle by ultrasound

利用超声波分散技术,制备了除草剂（唑嘧璜草胺）纳米颗粒,利用扫描电子显微镜（SEM）表征颗粒形貌,并研究了制备的唑嘧璜草胺纳米颗粒的稳定性。结果表明：在＂超声功率＂档位选择0.2kW条件下,以0.2g.mL^-1唑嘧璜草胺/二甲基甲酰胺溶液为分散相,以聚乙烯吡咯烷酮（PVP）水溶液为分散介质,PVP质量浓度为0.05mg.mL^-1时,制备的粉体粒径在50-150nm,呈近似球形。储藏稳定性研究表明,制备的唑嘧璜草胺纳米分散液不进行固液分离时,在2天内发生了重结晶现象,出现了粒径达3μm的大颗粒,所以应制备成干燥的纳米粉体进行储藏。超声波法利用药物在不同溶剂中的溶解性差异制备难溶药物的微米粉和纳米粉,方法简单、快捷、适用性广、可以方便地用于制备其它难溶或微溶的药物超微粉。

The ultrasonic dispersion method has been used to prepare flumetsulam nanoparticle, and SEM （scanning electron microscopy） is used to study the morphology of particle. It is confn-med that： the monodispersed flumetsulam monodisperse nanoparticles of 50nm-150nm flumetsulam can be prepared when PVP mass concentration is increased to 0.05mg.mL^-1 with the ultrasonic power of 0.2kW. A recrystallization phenomenon has been observed due to no solid-liquid separation in the storage of the nanosuspension, and 3μm particles could be formed in 2 days. So the flumetsulam nanoparticle should be stored in the form of dry powder. The ultrasonic method utilizes the difference of flumetsulam solubility in different solvent and is confirmed to be a simple, fast and applicable method for preparation of microparticles or nanoparticles of nonsoluble drug.