摘要
苦瓜籽含有许多具有抗HIV活性的核糖体失活蛋白,例如α-苦瓜素,β-苦瓜素和MAP30,它们还分别具有堕胎、抗肿瘤活性、抗乙肝病毒活性等。本文从结构、功能、抗HIV分子机制、与其它病毒作用、与其它药物相互作用等方面总结了MAP30蛋白的研究,并根据现有的聚乙二醇修饰方法对MAP30修饰研究提出了展望。
The seeds of bitter melon contains a lot of ribosome inactive protein（RIP）, such as α -momoreharin, β -momorcharin, MAP30, which have anti-HIV activity, as well as the activity of abortion, anti-tumor, anti-HBV, and so forth. This paper summarizes the research achievements of MAP30 in terms of its structure, function, molecule mechanism of anti-HIV, the effect on other virus and the interaction with other drugs. The future PEG modification research of MAP30 suggestions are given according to the existing methods of PEG modification.
出处
《生命科学仪器》
2009年第10期3-6,共4页
Life Science Instruments
