雷公藤硫氰酸基内酯醇的半合成研究

Study on the Semi-synthesis of Tripthiocyanatolide

目的合成雷公藤硫氰酸基内酯醇。方法以雷公藤甲素为起始原料,通过亲核取代反应生成雷公藤硫氰酸基内酯醇。结果总收率为 79.5%,目标化合物的结构经 IR、1H-NMR、MS 等方法确证。结论利用半合成技术开发高效低毒的新药是一条重要途径。

OBJECTIVE To synthesize the title compound. METHODS Tripthiocyanatolide was semi-synthesized by triptolide, which was a convenient starting material, through the reaction of nucleophilic substitution. RESULTS The total yield was 79.5%. The target compound was identified by IR, ^1H-NMR and MS. CONCLUSION It＇s very important to develop a new product with high effect and low toxicity by making use of 2-step synthesis technology.