富血小板血浆及所含相关因子在组织修复再生中的应用与作用

Application and effect of platelet-rich plasma and its relevant factors for tissue repair and regeneration

富血小板血浆是自体血离心后的产物,目前已广泛用于整形外科和口腔颌面外科。近年来研究发现富血小板血浆可以促进骨再生,血管发生,软组织修复以及和干细胞复合用于骨科领域和组织工程,这使得富血小板血浆成为热门的研究课题。另有报道富血小板血浆具有促进难愈合伤口的作用。文章简要叙述了富血小板血浆的主要组成成分、临床应用、对骨愈合和软组织修复等方面的作用机制以及富血小板血浆的最新研究进展,并讨论其目前临床应用上主要存在的问题。

Platelet-rich plasma （PRP） is a concentrated source of autologous platelets after centrifugation, being used widely in plastic surgery and oral-maxillofacial surgery. Recent studies have showed that PRP can improve bone repair, vasculogenesis, and soft tissue repair. Composite of PRP and stem cells is applied in the field of orthopedics and tissue engineering. As a matter of fact, PRP has become a hot research topic. In addition, PRP plays an important role in the healing of chronic wound. This paper briefly introduces the main components of PRP and its clinical application, the mechanism for bone healing and soft tissue repair, as well as the latest research achievement and discussion in the shortcoming of PRP in clinical application.