阿托伐他汀不同服药方法对血清低密度脂蛋白胆固醇的影响

Effect of every other day dose atorvastatin on serum LDL-cholesterol.

目的比较阿托伐他汀(立普妥)隔日口服与每日口服20 mg对血清低密度脂蛋白胆固醇(LDL-C)的疗效。方法对132例LDL-C升高的患者,前瞻、随机、非双盲分为每日口服组与隔日服药组。两组服药前剂量为20 mg。LDL-C>3.37 mmol/L(130mg/dl)为入选对象。在治疗前及治疗2个月后测LDL-C及高密度脂蛋白胆固醇(HDL-C)、总胆固醇(CT)、甘油三脂(TG)并进行对比,同时测谷丙转氨酶(SGPT)、谷草转氨酶(SGOT)、肌酸磷酸激酶(CK)及了解其他副作用。结果经治疗2个月后LDL-C水平均明显降低,LDL-C水平降低程度,隔日服药组为35.6%,每日服药组为38.5%,两组降低水平差异无统计学意义(P>0.05),SGPT,SGOT,Cre,CK及其他副作用差异无统计学意义(P<0.05)。结论阿托伐他汀隔日口服或每日口服药20 mg对降低LDL-C水平相似,副作用亦相似,但隔日服药降低了医疗费用并提高了服药依从性。

Objective To compare the effect of every other day and once day dose 20mg atorvastatin（ Lipitor） on the serum low density lipoprotain cholesterol （ LDL - C） levels. Methods This was a prospective, randonized, nonblinded clinical trial. The 132 caves of LDL- C 〉 3.37mmol/L （130 mg/dl） were randomiged into every other day group or once day group with 20mg atorvastatin. Before treatment and after 2 month, serum lipids, SGPT, SPOT, creatine kinase （CK） and so on were measured. The side effect were studied. Results In the every other day group, there was a 35.6% reduction in LDL - C levels; in the once day group, there was a 38.5% reduction at the end of two months. The diffreence between the changes in the LDL - C level of the two groups was found to be unstalistical dignificance （ P 〉 0.05 ）. Conclusion The every other day or once day does of 20mg atorvastatin have similar efficacious to reduce LDL - C level and similar safe, but the every other day does of 20mg atorvastatin may reduce cost and provide more compliance.