乌司他丁在肝动脉化疗栓塞中保护肝功能的疗效观察

Observing the Effect of Ulinastatin in the Protection of Liver Function in Hepatic Arterial Chemoembolization

目的:探讨乌司他丁对肝癌介入治疗后肝功能的保护作用。方法:96例原发性肝癌患者随机分为两组,对照组给予常规护肝治疗,治疗组加用乌司他丁治疗1周,20万u/日,监测两组肝功能变化情况。结果:两组病例治疗后均出现肝功能损害,术后d3治疗组ALT、AST、GGT、TB il上升幅度较对照组低,术后1周治疗组ALT、AST、TB il恢复至术前水平(P<0.05)。结论:乌司他丁在肝癌介入治疗中有显著的护肝作用。

Objective： To explore the effect of ulinastatin （ UTI ） in the protection of liver function in hepatic arterial chemoembolization therapy of hepatocellular carcinoma （ HCC ）. Method： 96 HCC patients were randomly assigned to receive routine therapy （ control group ） or routine therapy plus UTI （ trial group ）, with liver functional changes of two groups monitored. Result： Hepatic dysfunctions in both groups were observed after therapy. The increases of ALT, AST, GGT and TBil in trial group were lower than those in control group on the third post - therapy day, the level of ALT, AST and TBil in trial group recovered after one week （ P 〈 0.05 ）. Conclusion： UTI showed a satisfactory effect in the protection of hepatic function in the interventional therapy for HCC patients.