CDX2和p120-catenin在胃癌组织中的临床意义

The Significance of CDX2 and p120-catenin Protein Expression in Gastric Carcinoma

目的探讨胃癌组织中CDX2和P120-catenin表达与其浸润、转移及预后的关系。方法采用Maxvision“”免疫组化方法，检测88例胃癌组织中CDX2和P120-catenin表达情况。结果88例胃癌患者中肿瘤直径〈2cm者、肠型胃癌者、无淋巴结转移者、I期及无浆膜层受侵者CDX2阳性表达率分别为51．4％、45．8％、70．0％、71．4％、66．6％，均相应高于肿瘤直径〉2cm者、弥漫浸润型胃癌者、有淋巴结转移者、Ⅱ～Ⅳ期及浆膜层受侵者，对应各组阳性表达率比较具有显著性差异（P〈0．05）。88例胃癌患者中肠型胃癌者、无淋巴结转移者、I期及无浆膜层受侵者p120-catenin阳性表达率分别为40．6％、50．0％、53．5％、58．3％，均相应高于弥漫浸润型胃癌者、有淋巴结转移者、Ⅱ～Ⅳ期及浆膜层受侵者，对应各组阳性表达率比较具有显著性差异（P〈0．05）。结论CDX2和p120-catenin表达与胃癌的Lauren分型、有无淋巴结转移、TNM分期及肿瘤浸润深度相关，联合检测胃癌患者的CDX2和p120-catenin，可判断胃癌患者预后。

Objective To study the significance of the expression of CDX2 and pl20-catenin protein in gastric carcinoma. Methods The expression of CDX2 and pl20-catenin protein was detected with MaxvisionTM immunohistochemical method in 88 cases gastric carcinoma. Results There was no significant correlation between the positive expression of 88 cases pl20- catenin protein and cancer size;but there was significant correlation between the positive expression of CDX2 and pl20-catenin protein,Lauren type,invasion,lymph metastasis,TNM stage. Conclusion the CDX2 and pl20-catenin protein are useful markers of predicting the metastatic potential of gastric cancer, and detection of their expression may be useful for evaluating prognosis and guiding treatment.