RON、Hepsin和C-Met在浸润性乳腺癌中的表达及其意义

The Expression and Significance of RON,Hepsin and C-Met in Breast Cancer

目的探讨浸润性乳腺癌组织中RON和Hepsin、C-Met的免疫表达及其意义。方法采用免疫组化PV-6000法检测了87例浸润性乳腺癌组织中RON和Hepsin、C-Met基因的表达情况。结果Hepsin、C-Met、RON在87例浸润性乳腺癌组织中的阳性表达率分别为70.1%、64.4%、65.5%,三者的阳性表达两两呈正相关(P<0.01),同时与浸润性乳腺癌的病理学分级、淋巴结转移亦呈正相关性(P<0.01)。结论Hepsin、C-Met、RON与浸润性乳腺癌的预后因素有相关性,联合检测可以更好地提示患者的预后。

Objective To study the relationship and the significance among the expressions of hepsin, C-Met and RON in breast cancer. Methods The expression of hepsin, C-Met and RON in the tissues from 87 patients with breast cancer was analyzed by immunohsitochemistry. Results The expression of RON, Heosin and C-Met was positively correlated. The expression of RON,hepsin and C-Met was related to the pathological grade and lymph node metastasis. Conclusion Hepsin, C-Met and RON might related to the prognosis of breast cancer.