海珠明目滴眼液对白内障防治作用的实验研究

Effect of Haizhumingmu eye drops on cataract in rats

目的:研究海珠明目滴眼液对白内障的防治作用。方法:用半乳糖诱发大鼠白内障,测定晶体内的可溶性蛋白(SP)含量、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、谷胱甘肽过氧物酶(GSH-Px)和丙二醛(MDA)水平。结果:与生理盐水组比较,海珠明目滴眼液中、高剂量组大鼠晶体混浊的速度明显减慢、程度明显减轻(P<0.05);海珠明目滴眼液低、中、高剂量组大鼠晶体的SOD,GSH和GSH-Px含量均明显增高(P<0.05,P<0.01),而MDA含量明显降低(P<0.05,P<0.01),各组大鼠晶体SP含量无显著差异(P>0.05)。结论:海珠明目滴眼液具有保护晶体抗氧化防御体系的功能,能延缓和控制白内障的形成,对早期白内障具有较好的防治作用。

Objective： To investigate the effect of Haizhumingmu （HZMM） eye drops on cataract in rats. Methods： Cataract was induced by galactose in rats, and the levels of SP, SOD, GSH, GSH-Px and MDA in lenses were determined. Results：As compared with the control group, both the speed and the degree of cloudiness in lenses were significantly decreased by middle and high doses of HZMM eye drops （P 〈 0.05 and P 〈 0.01 ）. The levels of SOD, GSH and GSH-Px in lenses were significantly increased by low, middle and high doses of HZMM eye drops （P 〈 0.05 and P 〈 0.01 ） , the content of MDA in lenses was significantly decreased （ P 〈 0.05 and P 〈 0.01 ）, and the content of SP was not significantly affected in each group （P 〉 0.05）. Conclusion： HZMM eye drops can delay and control the formation of the cataract by inhibition of oxidation of the lens, suggesting a protective effect on early cataract.