摘要
目的观察补肾化瘀浸膏对实验性去势大鼠骨密度及骨组织形态的影响,探讨其对骨质疏松症的治疗作用。方法选用健康雌性SD大鼠48只,称质量后随机分为空白组,模型组,尼尔雌醇阳性对照组,补肾化瘀浸膏大、中、小剂量组,共6组,各8只,观察补肾化瘀浸膏对实验性骨质疏松症大鼠治疗作用。结果与模型组比较,补肾化瘀浸膏大、中剂量组大鼠骨密度显著增高(P<0.05),成骨细胞数目显著增多(P<0.05),破骨细胞数目显著减少(P<0.05);形态学观察显示,补肾化瘀浸膏各剂量组与模型组比较,骨小梁的宽度增大,间距变小,数量增多,排列较规则,结构整齐,骨髓腔变小。结论补肾化瘀浸膏对去势所致高转换型骨质疏松大鼠有较好的治疗作用,具有较高的临床应用和开发价值。
Objective To study effects of bushenhuayu extracts on bone density and morphology in ovaries-castrated rats. Methods 48 healthy SPF female SD rats were divided into blank group, model control group, nilestriot group as positive control;and bushenhuayu groups with high, middle and low-dose of treatent, respectively. Bone density and morphology was detected. Results Compared with models, high and middle-dose of bushenhuayu significantly increased the bone density（ P 〈 0.05 ） and amount of osteoblast（ P 〈0.05 ） , while lowered osteoclast（ P 〈 0.05 ）. The morphology data showed that the width of trabecularism was elevated, the amount was raised, structure was improved and gap shrinked in bushenhuayu treated groups as well. Conclusion Extract of busherthuayu has a potential therapeutic effect on the high -bone -turnover osteoporosis caused by ovaries-castrating, which is valuable for clinic application.
出处
《医药导报》
CAS
2009年第12期1533-1535,共3页
Herald of Medicine
基金
湖北省教育厅B类项目基金资助课题(基金编号:B20082412)
