摘要
目的:研究探讨黄韧带骨化的发病机制。方法:取30例腰椎管狭窄症行后路椎板切除减压病人的黄韧带,正常对照10例取自因急性腰椎外伤行后路探查减压术的青壮年黄韧带。用免疫组化法观察肥厚黄韧带标本BMP-2、TGF-β及IGF-I的表达。结果:BMP-2、TGF-β及IGF-I在肥厚的腰椎黄韧带中阳性表达,而在正常黄韧带中不表达。结论:黄韧带骨化可能基于黄韧带组织的肥厚、胶原纤维增生及软骨细胞的形成。
Objective：To study the etiology of the ossification of the spine ligamentum flavum（OLF）.Methods：The expressions of bone morphogenetic protein（BMP） 、transforming growth factor（TGF） and insulin-like growth factor（IGF） were investigated in 30 patients with lumbar spinal stenosis.Detecting the expression of BUP-2,TGF-β and IGF-I in ligamentum flavum hypertrophgin 10 normal adults using immunohistochemical staining technique.Results：BMP-2、TGF-β and IGF-I were expressed in chondrocyts.There were no expressing in normal ligaments. Conclusion：Ossification of the spine ligamentum flavum is based on hypertrophy of the ligamentum flavum, hyperplasia of collagen fiber and production of cartilage cell.
出处
《内蒙古医学院学报》
2009年第5期448-451,共4页
Acta Academiae Medicinae Neimongol
基金
内蒙古医学院青年项目(NY2006QN001)
