狼疮肾炎尿液标记物研究进展

STUDY PROGRESSION OF URINARY BIOMARKERS IN LUPUS NEPHRITIS

系统性红斑狼疮(SLE)以体内产生大量自身抗体和多器官脏器受累为特点的自身免疫性疾病,肾脏是最常见的受累器官,肾功能衰竭是SLE最重要的死亡原因之一。尿液是一种易获得,易保存的无创性生化标记物。因此,用尿液标记物反应狼疮肾炎(LN)的活动性、病理分级成为国内外学者研究热点。目前,研究发现尿液标记物转化生长因子-β1(TGF-β1)、白细胞介素,巨噬细胞炎性蛋白-1α(MIP-1α)、单核细胞趋化蛋白-1(MCP-1)、Lipocalin-2等对LN的诊断、分级有重要意义。

SLE is a kind of self-immune disease,which can produce numbers of self-antibody and violate numbers organs.Kidney is a common influenced organ.Renal failure is one of most important course of death because of SLE.Urine is a no damage biomarkers which is easily received and conserved.Thus many studies focus on that using urinary biomakers react activity and pathology classification of lupus nephritis.Currently,we bave found urinary biomakers such as TGF-β1、MIP-1α、MCP-1、Lipocalin-2 and so on.These urinary biomakers take important role in diagosis and classification of lupus nephritis.