不育症妇女宫颈沙眼衣原体和解脲脲原体检测及其治疗

The prevalence of Chlamydia trachomatis and Ureaplasma urealyticum cervical infection in infertility women and the observation of therapeutic efficacy

用细胞培养法、ＰＣＲ和ＩＦＡ检测１４５例不育症育龄妇女及４５例正常育龄妇女宫颈拭子沙眼衣原体（ＣＴ）及解脲脲原体（Ｕｕ），并以强力霉素和四环素治疗阳性病例。结果示，用细胞培养，ＰＣＲ，培养片ＩＦＡ及直接涂片ＩＦＡ检测不育症组宫颈ＣＴ，检出率分别为６２．７％，６６．８％，６４．８％和３６．５％，明显高于对照组（Ｐ＜０．０１）；Ｕｕ分离率为３３．１％；ＣＴ与Ｕｕ合并感染率为１８．６％，两者均明显高于对照组（Ｐ＜０．０１）。表明宫颈ＣＴ和Ｕｕ感染是引起女性不育的重要因素。强力霉素。

Objective: To study the prevalence of Chlamydia trachomatis (CT) and Ureaplasma urealyticum(Uu) cervical infection in infertility women, and therapeutic effectiveness of tetracycline and qianglimycin. Method: CT in cervical swab specimen was detected by cell culture, polymerase chain reaction(PCR) and immunofluorescent assay(IFA), Uu in cervical swab specimen was detected by culture, in a group of 145 infertility women, before and after treatment, and 45 women at productive age who attended obstetric and gynecologic clinic. Result: The positive rate of CT by cell culture, PCR, IFA(shell) and IFA(direct smear) was 62.7%,66.8%,64.8% and 36.5%, respectively, which was obviously higher than that of the control (P<0.01). The positive rate of Uu was 33.1%, that of CT and Uu co infection was 18.6%. Both were obviously higher than those of the control (P<0.01). Conclusion: This study indicates that the prevalence of CT and Uu cervical infection in infertility women is high. CT and Uu cervical infection is closely related to female infertility. The therapeutic effectiveness of tetracycline and qianglimycin is not ideal.