慢性肺心病病人血浆NO与PaO_2的测定及其相关性

Relationship between plasma NO and PaO 2 of artery blood in the patients with chronic pulmonary heart disease

分别测定２８例慢性肺心病患者急性发作期及好转期血浆一氧化氮（ＮＯ）含量。结果显示，急性发作期病人血ＮＯ明显降低。治疗缓解后，动脉血氧分压（ＰａＯ２）升高，ＮＯ含量亦明显增加。ＮＯ水平提高与ＰａＯ２提高呈明显正相关，提示慢性肺心病患者缺Ｏ２可能系通过抑制ＮＯ的合成释放致使肺心病加重；

The plasma nitric oxide(NO) level in the 28 patients with chronic pulmonary heart disease and health controls were measured. The results showed that NO level in the exacerbating patients and stable patients was significantly lower than that in health controls. The NO level in the patients getting worse was markedly lower than that in the stable patients. The lower the oxygen pressure of the artery blood (PaO 2), the lower the NO level. when the patient's situation was improving, the plasma NO level increased with rising PaO 2. The plasma NO level in patients was associated with the PaO 2. This study suggests that the sustained pulmonary hypertension caused by chronic hypoxia may relate to the reduction of NO synthesis and release. and that NO may play an important role in the pathogenesis in chronic pulmonary heart disease.