冠心病患者血小板PKC、PKCI及红细胞PKC活性变化的研究

Study on Activity Change of Hematoblastic PKC、PKCI and Erythrocytic PKC of Patients with Coronary Heart Disease

目的:研究蛋白激酶C(PKC)在冠心病的发生、发展中的作用。方法:测定87例心绞痛(AP)患者、91例急性心肌梗死(AMI)患者、90例健康对照(HC)者的血小板胞膜、胞浆PKC、胞浆蛋白激酶C抑制剂(PKCI)活性和红细胞膜、胞浆PKC活性。结果:AP组和AMI组血小板胞膜中PKC活性明显高于HC组,而胞浆中PKC活性明显低于HC组;AP组和AMI组血小板胞浆中PKCI活性明显低于HC组;AP组和AMI组红细胞胞膜中PKC活性明显高于HC组,而胞浆中PKC活性低于HC组。结论:PKC可能参与冠心病的发病。

Objective：To study the relationship between protein kinase C（PKC）and coronary heart disease. Meth- ods：To measure the activity of PKC and its inhibitor （PKCI）in platelets,the activity of PKC in erythrocytes from patients with angina pectoris （AP）. Patients with acute myocardial infarction （AMI）,and healthy control subjects （HC） respectively. Results ：The activity of PKC in membrane of platelets from AP and AMI were higher than those of HC,the activity of PKC in cytosol of platelets from AP and AMI were lower than those of HC ;The activity of PKC in membrame of erythrocytes from AP and AMI were higher than those of HC,the activity of PKC in cytosol of erythrocytes from AP and AMI were lower than those of HC . Conclusion ：PKC is likely to he associated with the pathogenesis of coronary heart disease.