含左氧氟沙星、埃索美拉唑的三联方案治疗幽门螺旋杆菌的初步探讨

Primary Discussion of Esomeprazole Plus Levofloxacin and Amoxicillin in Treatment of Helicobacter pylori

目的:探讨埃索美拉唑加左氧氟沙星加阿莫西林三联1周疗法根除幽门螺杆菌(HP)的疗效及安全性。方法:选择84例符合条件的HP阳性慢性胃炎和消化性溃疡患者,随机分为两组。治疗组采用埃索美拉唑(20mg,2次/d)加左氧氟沙星(200mg,2次/d)加阿莫西林(1000mg,2次/d),治疗7d;对照组采用埃索美拉唑(20mg,2次/d)加克拉霉素(250mg,2次/d)加阿莫西林(1000mg,2次/d),治疗7d;疗程结束4周后复查,观察HP根除率及不良反应。结果:治疗组对照组的HP根除率分别为90.69%和84.21%。两组无统计学差异(P>0.05)。结论:埃索美拉唑加左氧氟沙星加阿莫西林三联1周疗法是根除HP的理想方案。

Objective：To discuss the efficacy and safety of esomeprazole plus levofloxacin and amoxicillin for a week triple therapy to eradicate Helicobacter pylori（HP）. Methods：84 patients with H pylori infection accompanted with peptic or chronic gastrits were randomly divided into two groups. The therapy group using esomeprazole （20 mg, 2/ day） plus levofloxacin （200 mg, 2 times/day） amoxicillin （1 000 mg,2 times/day）, in the control group using esomeprazole （20 mg,2 times/day）-elarithromycin （250 mg, 2 times / day） amoxicillin （1000 mg, 2 tires / day）, the corse oftreatment was 7 days; 4 weeks after the end of the course observation HPeradication rate and adverse reactions. Results：The levofloxacin group of HP eradication rates were 93. 69 percent and the control group were 84. 21 percent. There was no significant difference between the two groups （P〉0.05）. Conclusion ：Esomeprazole plus levofloxacin and amoxicillin for one week triple therapy to eradicate HP infection is a ideal therapy.