川芎嗪联合甲钴胺治疗糖尿病周围神经病变疗效观察

Clinical observation of the curative effect of ligustrzing and mecobalamin on diabetic peripheral neuropathy

目的观察川芎嗪联合甲钴胺治疗糖尿病周围神经病变的疗效。方法76例患者随机分成观察组和对照组，均予甲钴胺治疗。观察组40例，给予80mg川芎嗪注射液加入生理盐水250ml及500μg的甲钴胺加入100ml生理盐水中静脉滴注，1次／d，共4周；对照组36例，单用500μg的甲钴胺静脉滴注，1次／d，共4周。结果观察组临床症状改善明显，较对照组显著提高（P〈0．05），神经传导速度也较对照组提高明显（P〈0．05）。结论川芎嗪与甲钴胺联合治疗糖尿病周围神经病变比单独使用甲钴胺效果好。

Objective To observe the effect of Ligustrzing and mecobalamin on diabetic peripheral neuropathy （DPN）. Methods Seventy - six patients with diabetic peripheral neuropathy were randomly divide into two groups. The treatment group （40 cases） were given Ligustrzing 80 mg solved in 250 ml NS and mecobalamin 500 μg solved in 100 ml NS intravenously every day for four weeks, control group （ 36 cases） were only given mecobalamin 500μg every day for fourweeks. Results The clinical symptoms in the treatment group and the control group were significantly improved （ P 〈 0. 05 ）, nerve conduction velocity was also signfieantly increased, the difference between two groups was significant（P 〈 0. 05 ）. Condusion Combined therapy of Ligustrzing and mecobalamin is better than that of mecobalamin for improvement of DPN symptoms.