浅表性膀胱癌术后复发和进展影响因素分析

Analysis of the prognostic factors affecting postoperative recurrence and progression in patients with superficial bladder transitional cell carcinoma

目的探讨影响浅表性膀胱移行细胞癌术后复发和进展的主要因素。方法初次收治浅表性膀胱移行细胞癌患者共150例，获得随访120例，对可能影响肿瘤复发和进展的因素（如病理特点、治疗方案等）进行Cox回归分析。结果平均随访84．7个月。3、5年的复发率分别为27．5％和36．7％，影响复发的主要因素是肿瘤病理分级、TNM分期、肿瘤数量、肿瘤复发情况，而肿瘤病理分级、TNM分期和肿瘤复发情况是肿瘤复发的独立危险因素。3、5年的进展率分别为9．2％和17．5％，影响进展的主要因素是肿瘤病理分级、TNM分期、肿瘤数量、肿瘤复发情况，而肿瘤病理分级是肿瘤进展的独立危险因素。结论肿瘤病理分级、TNM分期、肿瘤数量、肿瘤复发情况均是影响浅表性膀胱移行细胞癌术后复发和进展的独立危险因素。

Objective To evaluate the prognostic factors affecting postoperative recurrence and progression in patients with superficial bladder transitional cell carcinoma（SBTCC）. Methods From 2000 to 2004,150 patients with SBTCC were treated, of which 120 patients were followed up. The possible prognostic factors including clinical and pathological figures were analyzed by Cox＇s proportional hazard model in these patients. Results The mean follow-up period was 84. 7 months. The recurrence rates at 3-year,5-year were 27.5% and 36.7% respectively. The main variables affecting recurrence were histological grades ,tumor stage, tumor number and recurring tumor, and the first three were the independent risk factors. The progression rates at 3-year,5-year were 9.2% and 17.5%. The main variables affecting progression were histological grade, tumor stage, tumor number and recurring tumor, and the first one was the independent risk factor. Conclusion The main variables affecting progression were histological grade, tumor stage,tumor number and recurring tumor,and the first one were the independent risk factor.