不同食谱诱发地鼠形成两类不同胆石的实验研究

Study on gallstone formation induced by two different lithogenic diets in hamsters

目的探讨两类不同食谱诱发叙利亚金黄地鼠形成胆石情况。方法采用高糖无脂饲料诱发幼年叙利亚金黄地鼠形成胆固醇结石（ＣＨＳ），用低蛋白高纤维素饲料诱发成年叙利亚金黄地鼠形成胆色素结石（ＰＳ）。结果６周后两组动物的成石率分别为７０．１％和８０．０％，死亡率分别为１５％和０，其结石的胆固醇含量分别为９２％±４．７％和１７％±３．８％。结论叙利亚金黄地鼠是研究两类胆石形成的良好实验动物之一。

Objective To evaluate the formation of gallstone induced by two different lithogenic diets in golden syrian hamsters. Method The experimental cholesterol gallstones(CHS) were conduced in young golden syrian hamsters by a high glucose and fat free lithogenic diet, and the experimental pigment gallstones (PS) were conduced in adult golden syrian hamsters with a low protein diet. Results After the hamsters had been fed on lithogenic diets for 6 weeks, the rate of gallstone formation in the CHS and PS groups was 70 1% and 80% respectively. The mortality was 15% and 0 respectively. The cholesterol content of gallstones in two groups was 92%±4 7% and 17%±3 8% respectively. Conclusion The golden syrian hamster is an excellent experimental animal for cholelithiasis model for both cholesterol gallstone and pigment gallstone.