摘要
目的:探讨β受体阻滞剂美托洛尔(商品名倍他乐克)治疗慢性充血性心力衰竭(CHF)的临床疗效及应用时机。方法:将127例充血性心力衰竭患者随机分成观察组65例,对照组62例,均予强心、利尿、血管紧张素转换酶抑制荆等治疗,观察组加用倍他乐克。观察临床疗效、不良反应及应用时机。结果:观察组与对照组的总有效率分别为89.47%与75.81%,两组比较差异有显著性意义(P〈0.05);与对照组及治疗6个月后比较左室后壁厚度(LVPWT)、左室射血分数(LVEF)的差异有显著性意义(P〈0.05);两组患者不良反应的发生率无显著性差异(P〉0.05)。结论:及早应用美托洛尔治疗充血性心力衰竭安全有效,其长期疗效优于短期疗效。
Objective :To Study on Application of the time on Chronic Heart Failure Patients with β -blocker Objective To Observe the Clinical Curative Effect and Application of the Time of β - blocker metoprolol ( product namebetaloc) on Congestive Heart Failure (CHF.). Methods : The 127 congestive heart failure patients were divided into two groups randomly,one was the observer group(65patients) ,the other was the control group(62 patients). Both of them were treated with heart -beat strengthen, diuresis, and angiotensin converting enzyme inhibitor. In addition, the patients of observer group were treated with β - blocker betaloc. To observe clinical curative efect,adverse reactions and application of the time. Results :The total efective rate of observer group and control group were 89. 47% and 75.81% respectively ( P 〈 0.05 ) ; to compare the uhrasonic cardiogram parameter of observer group patients with it of control group after 6 months treatment, there was conspicuous diference in the tw o groups, such as left ventricular posterior wall thickness(LVPWT) and left ventricular ejection fraction(LVEF) ( P 〈 0.05 ) ; Two groups of patients the incidence of adverse reactions was no significant difference (P 〉 0.05 ). Conclusion :Early application of metoproloU on congestive heart failure(CHF) was safe and efective, the longterm efect surpassed short -term efect.