转移抑制基因nm23-H_1在肺癌中的表达及其与预后的关系

The expression of nm23-H_1 gene product and its relationship with prognosis in patients with non-small cell lung cancer

目的探讨人非小细胞肺癌中nm23-H_1的表达水平与肺癌转移和预后的关系。方法应用免疫组织化学法对146例人非小细胞肺癌中nm23-H_1的表达水平进行研究。结果肺癌中nm23-H_1表达水平明显低于癌旁肺组织和正常肺组织(P<0.01);转移癌nm23-H_1表达水平明显低于原发癌(P<0.01)。肺癌中nm23-H_1的表达水平与肺癌淋巴结受累状态,细胞的分化程度以及是否存在转移有密切关系(P<0.01或P<0.05)。nm23-H_1高表达组术后预后明显优于低表达组(P<0.01)。结论 nm23-H_1表达水平降低可能是肺癌转移的重要原因之一,检测肺癌中nm23-H_1的表达水平是预测肺癌转移和预后的有价值的检测手段。

Objective In order to explore the expression level of nm23-H_1 gene and its relationship with the metastasis and prognosis in human non-smaU cell lung cancer (NSCLC). Methods The expression level of nm23-H_1 gene product was determined in 14 NSCLC samples. Results The positive rate of nm23-H_1 expression in NSCLC was significantly lower than that in adjacent non-tumor lung tissue and that in normal lung tissue (P<0. 01). The nm23-H_1 expression level in metastatic cancer was significantly lower than that in primary cancer (P<0. 01). There were significant differences between nm23-H_1 expression and the status of lymph node metastasis, the grade of differentiation of the tumor and the tumor metas-tasis (P<0. 01 or P<0. 05). The average survival time and 3-year survival rate of patients with high nm23-H_1 expression were significantly higher than those with low nm23-H_1 expression (P<0. 01). Con-clusion The decrease of nm23-H_1 gene expression may be a key cause of lung cancer metastasis. Deter-ruination of nm23-H_1 expression is the most reliable test to predict metastasis and prognosis in patients with NSCLC.