瑞巴匹特对胃粘膜保护作用的实验研究

Effects of rebamipide on gastric mucosal protection in rats

目的：观察瑞巴匹特对空腹大鼠胃粘膜血流量（ＧＭＢＦ）、胃碱分泌的影响及对盐酸乙醇损伤胃粘膜的保护作用。方法：实验分３部分，每部分均包括５组，即对照组、替普瑞酮组及瑞巴匹特３０，１００，３００ｍｇ／ｋｇ组。前两部分分别观察用药后ＧＭＢＦ及胃灌流液ｐＨ值变化，第３部分观察各组动物用药后经０．１５ｍｏｌ／ＬＨＣｌ－４０％乙醇灌胃处理所致的胃粘膜溃疡面积。结果：１００ｍｇ／ｋｇ，３００ｍｇ／ｋｇ瑞巴匹特组ＧＭＢＦ平均升高（１４．５５±４．２９）×１０－２，（２１．１４±６．１９）×１０－２ｍｌｍｉｎ－１ｇ－１；胃灌流液ｐＨ值平均升高０．２５±０．１３及０．４１±０．１５；平均溃疡面积为（１９．６０±４．０９），（５．００±２．７５）ｍｍ２。上述数据与对照组比较，统计学差异显著（Ｐ＜０．０５）。结论：瑞巴匹特可增加ＧＭＢＦ。

Objective: To evaluate the effects of rebamipide on gastric mucosal blood flow (GMBF) and gastric bicarbonate secretion and its protective effect on gastric mucosal lesion by exposure to 0.15 mol/L HCl 40% ethanol in fasted rats. Methods: The study consisted of three parts with five groups each, which were control group, teprenone group, 30, 100 and 300 mg/kg rebamipide groups. The first two parts evaluated the changes of GMBF and pH of gastric perfusate after using these reagents. The third part evaluated the gastric mucosal ulcer area induced by exposure to 0.15 mol/L HCl 40% ethanol. Results: In the 100 mg/kg and 300 mg/kg rebamipide groups, the mean increases of GMBF were (14.55±4.29)×10 -2 ml·min -1 ·g -1 and (21.14±6.19)×10 -2 ml·min -1 ·g -1 ; and the mean increases of gastric perfusate pH were 0.25±0.13 and 0.41±0.15; the mean ulcer area were (19.60±4.09) mm 2 and (5.00±2.75) mm 2. The statistic differences between the above data and those of control group were significant. Conclusion: Rebamipide can increase GMBF, accelerate gastric bicarbonate secretion and partially prevent gastric mucosa lesion by exposure to 0.15 mol/L HCl 40% ethanol.