奥曲肽治疗急性胃粘膜病变及应激性溃疡出血疗效观察

A clinical efficacy of octreotide in treatment of acute gastric mucosal lesions and stress ulcer with bleeding

目的：探讨生长抑素类似物奥曲肽治疗急性胃粘膜病变及应激性溃疡出血的临床疗效。方法：应用奥曲肽治疗急性胃粘膜病变及应激性溃疡出血１１１例（男性７０例，女性４１例，平均年龄４３．６岁），给予奥曲肽０．１ｍｇ，静脉滴注，１次／８ｈ，共维持３ｄ。结果：２４，４８及７２ｈ止血率分别为１８．９％，２８．８％和３７．８％，３ｄ总止血率为８５．６％，无效率为１４．４％。未发现明显的毒副反应。结论：奥曲肽对严重创伤、烧伤、神经系统损伤、重要器官功能不良及衰竭。

Objective: To study the effects of octreotide on the acute gastric mucosal lesions (AGML) and stress ulcer (SU) with bleeding. Methods: One hundred and eleven patients with AGML and SU with bleeding were treated with octreotide (0.1 mg/8 h, iv, for 72 h). Results: Among 111 cases, bleeding stopped in 21 (18.9%) within 24 h, 32 (28.8%) within 48 h, 42 (37.8%) within 72 h, and total rate of bleeding stopped was 85.6% (95/111). No toxic effects were found. Conclusion: Octreotide is an effective drug in the treatment of patients with AGML and SU with bleeding.