顺铂联合γ射线对裸鼠卵巢癌腹腔播散的抑制作用

Inhibitory effects of cisplatin in combination with γ ray irradiation on abdominal dissemination of ovarian cancer in nude mice

目的：观察顺铂联合γ射线对卵巢癌腹腔播散的抑制作用。方法：采用裸鼠卵巢癌腹腔播散模型，用顺铂和γ射线照射进行治疗。结果：低剂量顺铂单独和联合γ射线可部分抑制、而高剂量顺铂联合γ射线可完全抑制卵巢癌的腹腔播散。结论：顺铂联合γ射线有协同抗卵巢癌的作用。

Objective: To investigate the inhibitory effects of cisplatin in combination with γ ray irradiation on the abdominal dissemination of ovarian cancer. Methods: After the model of the abdominal dissemination of ovarian cancer was established in nude mice, cisplatin in combination with γ ray irradiation was employed to treat the disease. Results: The abdominal dissemination of ovarian cancer was partly inhibited by low dose cisplatin in combination with γ ray irradiation while completely inhibited by high dose cisplatin in combination with γ ray irradiation. Conclusion: Cisplatin in combination with γ ray irradiation can exert synergistic effects of anti ovarian cancer.