培哚普利对糖尿病肾病内皮细胞功能的影响

Effects of perindopril on endothelial function in patients with diabetic nephropathy

目的：了解早期糖尿病肾病（ＤＮ）内皮细胞功能的变化及培哚普利的干预作用。方法：４４例无高血压、持续有微量白蛋白尿的ＮＩＤＤＭ患者被随机分为培哚普利治疗组和常规治疗组，测定ＦＢＧ、Ｆｓ、Ａｌｂ、ＴＸＢ２、６－Ｋ－ＰＧＦ１α和ＥＴ－１以观察肾功能和内皮细胞功能的变化。结果：８周的培哚普利治疗改善了ＤＮ患者受损的内皮细胞功能，表现为血浆内皮素（ＥＴ）水平下降、６－ｋ－ＰＧＦ１α显著升高（Ｐ＜０．０１），较常规治疗差异显著。结论：培哚普利对ＤＮ肾功能的保护作用和其改善内皮细胞功能密切相关。

Objective: To investigate the effects of perindopril on endothelial function in the early stage of diabetic nephropathy. Methods: Forty four cases of non insulin dependent diabetes mellitus with microalbuminuria and normotension were randomized into the routinely treated group (RG) and perindopril treated group (PG). Results: After 8 week andministration of perindopril, the plasma ET level was significantly decreased and plasma 6 k PGF 1α concentration markedly increased in the PG as compared with the RG ( P <0.01 ). Conclusion: Perindopril might protect renal function through improving endothelia function during diabetic nephropathy.