卡孕拴和米索前列醇联合缩宫素预防剖宫产产后出血的临床观察

Clinical study on preventive effect of carboprost methylate and misoprostol combined with oxytocin on lying-in hemorrhage after uterine-incision delivery

目的观察卡孕拴和米索前列醇联合缩宫素预防剖宫产产后出血的临床效果。方法剖宫产者150例随机分为三组。实验组Ⅰ:于胎儿娩出后静脉注射缩宫素20U,并舌下含服卡孕栓1mg。实验组Ⅱ:于胎儿娩出后静脉注射缩宫素20U,并肛塞米索前列醇600μg。对照组:于胎儿娩出后静脉注射缩宫素20U。分别观察三组产后2h及24h阴道出血情况。结果实验组产妇产后2h及24h出血量与对照组相比明显减少,差异有显著意义(P<0.05)。结论卡孕拴和米索前列醇联合缩宫素预防剖宫产产后出血效果良好,副作用少,值得临床推广。

Objective To study the clinic effect of carboprost Methylate and misoprostol combined with oxytocin in preventing the postoperative vaginal bleeding. Methods 150 cases were randomly assigned in three groups. Test group Ⅰ ： patients were treated with oxytoein20u and received Carboprost Methylate lmg sublingually after fetal disengagement. Test group Ⅱ ： patients were treated with oxytocin20uthough intravenoation and received Misoprostol in rectum after fetal disengagement. Control group： patients were treated with oxytocin20 uby mainline after fetal disengagement. After the treatment, the amount of hemorrhage of three group within 2 hour and 24 hour were observed. Results Compared with control group, the amount of hemorrhage of test group within 2 hour and 24 hour were evidently smaller, there were significant level between them （P 〈0. 1）. Conclusions It is effective, few side-effect and worthy to be generalized in clinic for carboprost methylate and misoprostol combined with oxytocin on lying-in hemorrhage after uterine-incision delivery..