益肾壮督与蠲痹通络法治疗强直性脊柱炎85例的临床分析

Treatment of 85 cases of Ankylosing Spondylitis by Supplementing Kidney and Strengthening Du Meridian & Removing Arthralgia and Dredging Collaterals

目的:探讨益肾壮督、蠲痹通络法治疗强直性脊柱炎(AS)的疗效及安全性。方法:根据国际通用评价指标,对85例接受益肾壮督、蠲痹通络法治疗6个月以上的AS确诊患者进行回顾性分析。结果:与治疗前相比,患者症状体征评分(BASDAI)、躯体功能评分(BASFI)及骨骼和肌肉系统活动度的评分(BASMI)显著改善,血沉(ESR)、C反应蛋白(CRP)水平显著降低,骶髂关节炎程度明显减轻(P<0.01)。74例血清HLA-B27阳性患者中,有33例转阴,占44.59%。治疗期间有部分患者出现不良反应,经对症处理后均可缓解,无明显外周血象改变和肝肾功能损害。结论:益肾壮督以治本,蠲痹通络以治标的治疗大法治疗AS安全有效,值得临床进一步深入研究。

Objective： To investigate the efficacy and safety of treating ankylosing spondylitis （AS） with ＂supplementing kidney and strengthening du meridian ＆ removing arthralgia and dredging collaterals＂ therapy. Methods：A retrospective analysis about 85 cases of AS who received the treatment of supplementing kidney and strengthening du meridian ＆ removing arthralgia and dredging collaterals for more than 6 months was carried out in accordance with international evaluation measures. Results： After the treatment, the bath ankylosing Spondylitis disease activity index （BASDAf）, bath ankylosing spody litis functional index （BASFI） and bath ankylosing spondylitis metrology index （BASMI） of the patients were ameliorated significantly, and the level of erythrocyte sedimentation rate （ESR） and C-reactive protein （CRP） was significantly reduced. The sacroiliitis was also reduced significantly（ P 〈 0.01 ）. A total of 33 cases out of 74 cases of serum HLA-B27 positive patients became negative, accounting for 44.59%. During treatment, adverse reactions were observed in some patients and alleviated by expectant treatment. There was no obvious damage to peripheral blood, liver and kidney function of all the patients. Conclusion：The retrospective analysis showed that the therapy with ＂supplementing kidney and strengthening du meridian＂ for the root and ＂removing arthralgia and dredging collaterals＂ for the symptom, is a safe and effective treatment measure for AS and is worthy of further study.