芪白平肺胶囊对慢阻肺痰瘀阻肺证模型大鼠肺功能的影响

Effects of"Qibai Pingfei Capsule"on Pulmonary Function of Rats with COPD of Phlegm and Blood Stasis Pattern

目的:探讨芪白平肺胶囊(原名金泰胶囊)对痰瘀阻肺证慢阻肺模型大鼠肺功能的影响。方法:采用复合因素造模方法复制痰瘀阻肺证慢阻肺大鼠模型,造模的同时给予芪白平肺胶囊、川芎嗪、硝苯地平,观察大鼠一般状况,并测定第零点3秒用力呼气容量(FEV0.3)、用力肺活量(FVC)、呼气峰流速(PEF)等肺功能指标。结果:模型组FVC、FEV0.3、FEV0.3/FVC等指标较正常组明显下降(P<0.01);硝苯地平组各参数较模型组无改善,川芎嗪组FVC、FEV0.3、FEV0.3/FVC较模型组有明显改善(P<0.01);芪白平肺胶囊可明显提高FVC、FEV0.3、FEV0.3/FVC(P<0.01),且高剂量组与正常组无差异,但明显优于低剂量组,呈剂量依存性。结论:芪白平肺胶囊可有效阻止痰瘀阻肺证慢阻肺模型大鼠肺功能的下降。

Objective：To investigate the effects of ＂Qibai Pingfei Capsule＂ on the pulmonary function of rats with COPD of phlegm and blood stasis pattern. Methods： The COPD model of phlegm and blood stasis pattern in rats was duplicated with Composite Factor Method. At the same time of modeling, the rats were given the treatment of ＂Qibai Pingfei Capsule＂, tetramethylpyrazine and nifedipine respectively. The general state and the indicators of pulmonary function such as FEV0.3, FVC, PEF, etc of the rats were observed. Results： In comparison with normal group, the indicators of pulmonary function of model group decreased significantly（P 〈0. 01 ） ; there were no significant improvements in nifedipine groups; the indicators were improved significantly in tetramethylpyrazine group compared with model group （ P 〈 0.01 ） ; ＂ Qibai Pirtgfei Capsule＂ could improve FVC, FEV0. 3, FEV0. 3/FVC significandy （ P 〈 0.01 ）, and ＇there was no significant difference between high＇dose group and normal group. The effects of high-dose group was much better than that of low-dose group in a dose-dependent manner. Conclusion： ＂Qibai Pingfei Capsule＂ can effectively prevent the decline of pulmonary function of rats with COPD of phlegm and blood stasis pattern.