小叶榕不同提取物的主要药效学研究

Main pharmacodynamics study on the different extracts of Ficus microcarpa leaves

为研究小叶榕不同提取部位的镇咳、抗炎作用,采用氨水致咳小鼠动物模型、枸橼酸致咳豚鼠动物模型来评价小叶榕不同提取部位的镇咳作用;采用二甲苯滴耳廓致肿胀的小鼠动物模型、大鼠棉球肉芽肿动物模型来评价小叶榕不同提取部位的抗炎作用。结果表明:小叶榕醇沉不溶物能延长小鼠和豚鼠的咳嗽潜伏期,但不能减少咳嗽次数,小叶榕水提物、水提醇沉溶解物、大孔吸附树脂吸附洗脱物能延长小鼠和豚鼠的咳嗽潜伏期,并能减少咳嗽次数,其中水提醇沉溶解物镇咳作用最强;小叶榕醇沉不溶物不能减轻二甲苯引起的小鼠耳廓肿胀的程度,能减轻大鼠棉球肉芽肿足跖肿胀的程度,但效果不明显,小叶榕水提物、水提醇沉溶解物、大孔吸附树脂吸附洗脱物均能明显减轻二甲苯引起的小鼠耳廓肿胀的程度,并能明显减轻大鼠棉球肉芽肿足跖肿胀的程度。这表明国产小叶榕不同提取部位具有明显的镇咳、抗炎作用。

The effects of relieving cough and resisting inflammation of different extracts from Ficus microcarpa leaves were studied. The models of cough mouse caused by ammonia water and citric acid were used to evaluate the relieving cough effect;the models of swelling mouse auricles caused by dropping xylene,and the models of big mouse granuloma caused by cotton bails were used to evaluate the resist inflammation effect. The results were as follows： the F. microcarpa leaves extracts of water extracting,water extracting-alcohol precipitating dissoluble position,the position absorbed by macroreticular adsorbent resin and dissolved by solutions could extend cough incubation period of the mouse and guinea pig,reduce the coughing numbers. The above extracts could obviously lighten the swelling mouse auricles caused by dropping xylene and the big mouse granuloma caused by cotton bails. So the different extracts from F. microcarpa leaves had obvious effects on relieving cough and resist inflammation.