摘要
目的探讨C-erbB-2和葡萄糖转运蛋白1(Glut-1)在不典型增生子宫内膜和子宫内膜腺癌中的表达特点及其相互关系。方法应用免疫组织化学方法检测Glut-1、C-erbB-2在30例正常增生期子宫内膜、32例不典型增生子宫内膜和35例子宫内膜腺癌中的表达,并结合临床资料进行分析。结果Glut-1、C-erbB-2在各组中的阳性表达率增生期子宫内膜均为0,不典型增生组分别为46.9%和59.4%,子宫内膜腺癌组82.9%,74.3%;二者在各试验组间均有显著差异(P<0.005)。不典型增生组和子宫内膜腺癌组间差异有显著性(P<0.005)。Glut-1与C-erbB-2在各组的表达呈显著正相关关系(P<0.01)。结论Glut-1和C-erbB-2在子宫内膜腺癌的发生、发展中起着协同而独立的作用,对其进行联合检测有助于子宫内膜腺癌及癌前病变的早期诊断。
Objective Propose To study the expression of Glut-1 and C-erbB-2 in adenocarcinoma and atypical hyperplasia of endometrium and to explore their significance and correlation. Methods Immunohistocbemistry method（SP） was used to examine the expression of Glut-1 and C-erbB-2 in 30 cases of normal proliferative endometrium, 32 cases of atypical endometrial hyperplasia and 35 cases of endometrial adenocarcinoma. Their clinical data was observed. Results The expression of Glut-1 and C-erbB-2 had not been detected in normal proliferative endemetrium, the expression rate was 46.9 % and 59.4 % in atypical endometrial hyperplasia, 82.9 % and 74.3 % in endometrial adenocarcinoma. There were significant differences among normal proliferative endometrium, atypical hyperplasia and adenocarcinoma of endometrium. The difference between atypical hyperplasia and adenocarcinoma of endomemun were statistically significant. Positive correlation was also found between Glut- 1 and C-erbB-2 expression（ P 〈0. 01 ）. Conclusion Glut-1 and C-erbB-2 may play certain role in oncogenesis and progression of endometrial adenocarcinoma to different extent. Detection of Glut-1 together with C-erbB-2 is valuable for early diagnosis of adenocarcinoma and precancerous lesion.
出处
《中国实验诊断学》
北大核心
2009年第11期1555-1557,共3页
Chinese Journal of Laboratory Diagnosis
