卡前列素氨丁三醇预防高危孕产妇产后出血的疗效观察

The effeet and safety of Carboprost on prevention postpartum hemorrhage in high risk pregnant women

目的探讨预防高危孕产妇更佳的产后出血的方法。方法有潜在产后出血因素的高危孕产妇91例,随机分为两组,对照组48例,予缩宫素静脉滴注,观察组43例,在对照组基础上,应用卡前列素氨丁三醇宫颈肌内注射。观察两组产妇分娩时及产后2、24h出血量,比较两组产妇的出血率及输血率。结果观察组2h出血量(210.0±19.5)ml,24h出血量(361.0±130.5)ml,明显低于对照组的(312.5±38.7)ml、(525.6±110.8)ml,差异有统计学意义(P<0.05);产后出血率及输血率的比较,观察组分别为6.98%和2.33%,明显低于对照组22.92%和14.58%,差异有统计学意义(P<0.05)。结论应用缩宫素同时宫颈肌内注射卡前列素氨丁三醇,可有效预防产后出血。

Objective To investigate the effect and safety of carboprost on prevention postpartum hemorrhage in high risk pregnant women. Methods 91 patients with high risk to postpartum hemorrhage were randomly divided into two groups. The control group were given with oxytocin intravascularly and the study group was given with carboprost and with oxytocin intravasculaxly. Carboprost was injected into cervix after fetal disengagement. The differences of amount of bleeding during different time between the two groups were compared. Results The amount of bleeding in study group of different time was obviously less than the control group,with（210. 0±19.5）ml VS （312. 5±38.7）ml after 2hs,and（361.0±130. 5）ml VS（525.6±110. 8）ml after 24hs. The incidence rate of postpartum hemorrhage and blood transfusion was much lower in study group（6. 98% and 2.33% ） than that in controlgroup（ 22. 92% and 14.58% ）. The differences were of statistical significance （ P〈0.05 ）. Conclusion The preventive use of carboprost in high risk pregnant women to postpartum hemorrhage attained much better effects, and reduced the incidence rate of postpartum hemorrhage and blood transfusion.