肠易激综合征不同中医证型与5-HT的相关性研究

Research of the Relevance between 5-Hydroxy Tryptamine and Differentiated Types of Traditional Chinese Medicine in Irritable Bowel Syndrome

目的从胃肠神经-内分泌学的角度探讨肠易激综合征中医证型的病理实质。方法选肝郁气滞证、肝气乘脾证和脾胃虚弱证三种中医证型的患者及正常对照者各20例,采用荧光分光光度法测定血清中5-HT的浓度,比较血清5-HT浓度在三个证型中的变化。结果肝气乘脾证和脾胃虚弱证中血清5-HT的浓度升高显著,且肝气乘脾证有高于脾胃虚弱证的趋势。结论5-HT有可能成为IBS中医微观辨证的客观依据之一。

Objective To explore the pathogenic substance of the differentiated TCM types of irritable bowel syndrome （IBS） in view of gastrointestinal nerve - endocrinology. Methods Three TCM differentiated types, named liver qi stagnation,liver qi overacting the spleen and deficiency of the spleen and stomach ; as well as normal control groups were divided ,20 cases in each one. The spectrofluorophotometry was adopted to detect the concentration of 5 - HT in serum and compare the changes of 5 - HT concentration in serum among three differentiated syndromes of TCM. Results The concentration of 5 - HT in serum increased sig- nificantly in either liver qi stagnation or deficiency of the spleen and stomach. The concentration of 5 - HT was higher in tendency than that in deficiency of the spleen and stomach syndrome. Conclusion 5 - HT is probably one of the objective evidences for the microcosmic syndrome differentiation of IBS in traditional Chinese medicine.