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干扰素-γ和白细胞介素-4基因多态性与支气管哮喘 被引量：2

IFN-γ and IL-4 gene polymorphisms in bronchial asthma
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摘要 支气管哮喘是一种呼吸系统的慢性炎症性疾病,干扰素(IFN)-γ和白细胞介素(IL)-4在其发病中起重要作用。近年来有关这两种细胞因子基因多态性与哮喘相关性的研究不少。多数研究表明IFN-γ基因的CA重复序列、+874T/A和+5644A/T,IL-4基因的-589C/T和-33C/T多态性与哮喘易感性及哮喘表型存在相关性,而对IFN-γ基因-179G/T多态性的研究甚少。本文就IFN-γ和IL-4基因多态性与哮喘的关系作一综述。 Bronchial asthma is a chronic inflammatory disease Interferon-3, （IFN-γ） and inteleukin-4 （ IL-4 ） play a crucial role in development of asthma. In recent years, many studies about IFN-γ and IL-4 gene polymorphisms in bronchial asthma have been performed. Most studies indicated that the CA repeat element, ＋ 874T/A and ＋5644A/T of IFN-γ gene as well as the -589C/T and -33C/T of IL-4 gene had close correlation with asthma susceptibility and asthma phenotypes, whereas there were few studies about the -179G/T polymorphism of IFN-γ gene. In this review, we summarized the association of IFN-γ and IL-4 gene polymorphisms with asthma.
作者 吴敬芳 黄花荣
机构地区 中山大学附属第二医院儿科
出处 《国际内科学杂志》 CAS 2009年第11期676-678,682,共4页 International Journal of Internal Medicine
关键词 干扰素-Γ 白细胞介素-4 基因 多态性 哮喘 Interferon-γ Interleukin-4 Gene Polymorphism Asthma
分类号 R562.25 [医药卫生—呼吸系统]
  • 相关文献

参考文献20

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二级参考文献11

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共引文献26

同被引文献22

  • 1黄花荣,刘甜甜,魏菁,吴葆菁,檀卫平,麦贤弟.哮喘患儿的外周血淋巴细胞CD40/CD40L的表达及其与Tc1和Tc2的关系[J].中山大学学报（医学科学版）,2007,28(1):79-82. 被引量：3
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国际内科学杂志
2009年 第11期

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