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药物基因组学与高血压的个性化治疗 被引量:2

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摘要 不同个体对降压药物的治疗效果反应不同,多项研究发现基因多态性与不同个体对降压药物的反应之间存在一定联系。药物基因组学从基因水平研究多态性与药物效应多样性之间的关系,从而推动个性化用药,提高用药的安全性和有效性。文章介绍临床常用降压药与基因多态性的关系,预测药物基因组学在高血压个性化治疗中的前景。
作者 徐蕙枫 罗明
出处 《国际心血管病杂志》 2009年第6期385-388,共4页 International Journal of Cardiovascular Disease
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参考文献17

  • 1Arnett DK. Claas SA, Glasser SP. Pharmacogenetics of antihypertensive treatment[J]. Vascul Pharmacol, 2006, 44(2) :107-118.
  • 2Stavroulakis GA, Makris TK. Krespi PG, et al. Predicting response to chronic antihypertensive treatment with fosinopril: the role of angiotensin-eonverting enzyme gene polymorphism[J]. Cardiovase Drugs Ther. 2000, 14(4):427-432.
  • 3Li X, Du Y. Huang X, et al. Correlation of angiotensin-converting enzyme gene polymorphism with effect of antihy-pertensive therapy by angiotensin converting enzyme inhibitor [J]. J Cardiovasc Pharmacol Ther, 2003. 8(1):25-30.
  • 4Ohmichi N. Iwai N, Uchida Y. et al. Relationship between the response to the angiotensin converting enzyme inhibitor imidapril and the angiotensin converting enzyme genotype[J]. Am J Hypertens. 1997, 10(8): 951-955.
  • 5Bis JC. Smith NL, Psaty BM, et al. Angiotensinogen Met235Thr polymorphism, angiotensin converting enzyme inhibitor therapy, and the risk of nonfatal stroke or myocardial infarction in hypertensive patients[J]. Am J Hypertens, 20O3, 16(12) : 1011-1017.
  • 6Mondorf UF, Russ A. Wiesemann A, et al. Contribution of angiotensin Ⅰ converting enzyme gene polymorphism and angiotensinogen gene polymorphism to blood pressure regulation in essential hypertension[J]. Am J Hypertens, 1998, 11 (2):174-183.
  • 7Kurland L, Melhus H, Karlsson J, et al. Angiotensin converting enzyme gene polymorphism predicts blood pressure response to angiotensin Ⅱ receptor type 1 antagonist treatment in hypertensive patients[J]. Am J Hypertens, 2001, 19(10):1783-1787.
  • 8Ortlepp JR, Hanrath P, Mevissen V, et al. Variants of the CYP11B2 gene predict response to therapy with cande sartan[J]. Eur J Pharmacol.2002, 445(1-2): 151-152.
  • 9华琦,李东宝,皮林,陈海翎.内皮型一氧化氮合酶基因T786C多态性与缬沙坦降压疗效的关系[J].高血压杂志,2004,12(4):331-334. 被引量:10
  • 10Redon J. Luque Otero M, Martell N, et al. Renin angiotensin system gene polymorphisms: relationship with blood pressure and rnicroalbunlinuria in telmisartan treated hypertensive patients[J]. Pharmacogenomies J, 2005, 5(1): 14-20.

二级参考文献6

  • 1Brown MJ.Causes of essential hypertension:can it be cured[J] ? J Hum Hypertens,1993,7:387-390.
  • 2Hyndman ME,Parsons HG,Verma S,et al.The T786C mutation in endothelial nitric oxide synthase is associated with hypertension[J].Hypertension,2002,39:919-922.
  • 3Lifton RP.Genetic determinant of human hypertension[J].Proc Natl Cad Sci USA,1955,92(19):8545-51.
  • 4Nakayama M,Yasue H,Yoshimura,et al.T786C mutation in the 5'-flanking region of the endotheli al nitric oxide synthase gene is associated with coronary spasm[J].Circulation,1999,99:2664-2870.
  • 5Tsujita Y,Baba S,Yamauchi R,et al.Association analyses between genetic polymorphisms of endothelial nitric oxide synthase gene and hypertension in Japanese:the suit study[J].J Hypertens,2001,19(11):1941-8.
  • 6Kajiyama N,Saito Y,Miyamoto Y,et al.Lack of association between T786-C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene and essential hypertension [J].HypertensRes,2000,23(6):561-5.

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