O亚型叉头框蛋白质翻译后修饰研究进展

Research progress of post-translational modification of the forkhead box subtype O proteins

O亚型叉头框[forkhead box (FOX) subtype O,FOXO]蛋白质是FOX蛋白质转录因子家族的重要亚家族成员,在诱导细胞凋亡、DNA损伤修复、拮抗氧化应激、抑制细胞增殖、延长寿命和抑制肿瘤方面发挥重要作用。磷酸化、乙酰化、去乙酰化、泛素化和甲基化等翻译后修饰在其转录活性调控中发挥关键性作用。本文将主要就FOXO蛋白质亚家族成员的翻译后修饰和转录活性调节机制等方面的研究进展作一综述。

Forkhead box subtype O （FOXO） proteins, important subfamily members of the forkhead transcription factors, play critical roles in apoptosis induction, DNA injury repair, oxidative stress antagonism, proliferation inhibition, lifespan elongation and tumor suppression. The post-translational modifications, including phosphorylation, acetylation, deacetylation, ubiquitination and methylation play key roles in the regulation of their transcriptional activities. This review will mainly focus on the research progressions of post-translational modifications and the regulatory mechanisms of transcriptional activities of the FOXO subfamily members.