急性胰腺炎患者细胞因子改变及其临床意义探讨

CHANGES AND CLINIC SIGNIFICANCE OF CYTOKINES IN PATIENTS WITH ACUTE PANCREATITIS

对起病４天以内入院的２３例急性胰腺炎患者血中３种细胞因子即ＴＮＦ、ＩＬ１和ＩＬ６的变化情况进行动态观察，并分析其变化规律，以探讨其在判断病情严重性和估计预后中的价值。结果显示：所有患者血中３种细胞因子均升高，入院第１天轻、重症组ＴＮＦ和ＩＬ１有显著差异，而ＩＬ６则在１周后才出现显著性差异。由此表明，在病程的不同阶段选择恰当的细胞因子指标有助于病情严重性的判断。细胞因子与急性胰腺炎多器官衰竭的关系尚需进一步探讨。

The serum activities of 3 cytokines (TNF,IL 1 and IL 6) were observed in 23 patients admitted within 4 days of onset of acute pancreatitis (AP). The results showed that the serum level of 3 cytokines raised in all of the AP patients, significant difference between TNF and IL 1 was abserved at admission and IL 6 did after one week of admission, suggesting that proper cytokine criteria are useful in predicting severity of the disease but the relationship between cytokines and MOF had not established.