树突状细胞与乙肝慢性化的关系及树突状细胞疫苗相关研究进展

The role of dendritic cells in the pathogenesis of chronic hepatitis B and the research of vaccine dendritic cell

乙型肝炎的发病机制非常复杂，肝细胞病变主要取决于机体的免疫状态。免疫应答既可清除病毒，同时亦导致肝细胞损伤，甚至迫使病毒变异。目前研究证实，在HBV感染中存在抗原提呈功能的缺陷，特别是DC功能的缺陷，而且这种特异性的免疫调节和抗原提呈功能缺陷导致感染HBV后会成为HBV携带状态。

The pathogenesis of hepatitis B is complecated, The liver cell lesions primarily depend on the immune status of the body. Immune responses can clear the virus, but they can also cause liver cell injury and even resah in virus variation. The present studies confirmed that the defect of antigen-prensenting fuction, especially the defect of DC function is existed in the infection of HBV. The deficiency of specific immune regulation and antigen-presenting is the cansitive factor that drives the individual becomes HBV carrier after HBV infection. To apply the powerful immune function of DC to active immunotherapy is likely to be one of the principal methods for the treatment of chronic hepatitis B.