摘要
Th17细胞是近年发现的不同于Th1细胞和Th2细胞的新型CD4^＋T细胞亚群。活化的Th17细胞可分泌IL—17、肿瘤坏死因子-α（TNF—α）、IL-6、粒-单核细胞集落刺激因子（GM—CSF）等多种促炎症因子，Th17细胞不适当的激活与多种自身免疫性疾病和过敏性疾病密切相关。在体内阻断Th17细胞的分化、扩增及其相关细胞因子可预防、延缓或阻止自身免疫性疾病的发生、发展。
Resent studies indicated that IL-17-producing Th17 cells subset is a new lineage of CD^＋ effeetor T helper ceils distinct from the traditional Thl and Th2 cell. Activated Th17 cell subset has crucial roles in autoinunune and allergic disorders. Inhibiting the differentiation and proliferation of Th17 cells subsets, as well as its major effect factor may prevent or delay the development of autoimmune diseases.
出处
《国际免疫学杂志》
CAS
北大核心
2009年第6期461-464,共4页
International Journal of Immunology
