摘要
目的:测定服用抗癫痫中药制剂患者血清西药成分的浓度,以利于其合理应用。方法:2006年9月至2007年9月176例服用抗癫痫中药制剂的癫痫患者纳入研究,其中男102例,女74例,年龄3~63岁,平均年龄(26.27±11.67)岁;患病时间1~42年,平均(11.9±8.7)年。采用荧光偏振免疫法测定患者空腹血清苯妥英、苯巴比妥、丙戊酸和卡马西平的浓度。结果:176份血样中,174份含有1种或1种以上上述西药成分。2例服用化风丹和琥珀抱龙丸患者的血样中未检出西药成分。132例单用中药制剂,44例联用中西药制剂。169例患者的病情未得到控制,其中9例患者苯巴比妥的血浓度超出有效浓度上限。9例中有2例出现嗜睡和智力下降。结论:临床使用抗癫痫中药制剂应加强血药浓度监测,以利于合理用药。
Objective: To determine the serum concentrations of western medicine compositions in patients taking traditional Chinese antiepileptic preparations in order to benefit their rational use. Methods: From September 2006 to September 2007, 176 epileptic patients taking traditional Chinese antiepileptie preparations were enrolled in the study. The patients comprised 102 men and 74 women aged 3 - 63 years [ average age ( 26.27± 11.67 ) ]. Their disease duration was 1 - 42 years [ average disease duration (11.9 ± 8.68) years]. The patients' fasting serum phenytoin, phenobarbital, valproate, and carbamazepine concentrations were determined with fluorescence polarization immunoassay. Results: Of 176 blood samples, 174 contained one or more than one the above-mentioned western medicine compositions, but the western medicine composition was not detected in two blood samples from the two patients receiving Huafeng pills and Hupobaolong pills. One hundred and thirty-two patients took traditional Chinese medicine alone and 44 patients took traditional Chinese medicine combined with western medicine. One hundred and sixty-nine epileptic patients' condition was not controlled; of them, 9 patients' blood phenobarbital level is over the upper limit of effective concentration, and 2 of the 9 patients developed somnolence and decreased mentality. Conclusion: Close monitoring of blood drug concentration should be performed during the clinical use of traditional Chinese antiepileptic preparations for benefit to rational drug use.
出处
《药物不良反应杂志》
2009年第5期321-324,共4页
Adverse Drug Reactions Journal
关键词
癫痫
抗癫痫中药制剂
血药浓度
安全性
epilepsy
traditional Chinese antiepileptic preparations
blood drug concentration
safety